Transient cervical nerve root compression modulates pain: Load thresholds for allodynia and sustained changes in spinal neuropeptide expression
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چکیده
منابع مشابه
Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expression.
Nerve root compression produces chronic pain and altered spinal neuropeptide expression. This study utilized controlled transient loading in a rat model of painful cervical nerve root compression to investigate the dependence of mechanical allodynia on load magnitude. Injury loads (0-110mN) were applied quasistatically using a customized loading device, and load thresholds to produce maintained...
متن کاملSpinal neuropeptide responses in persistent and transient pain following cervical nerve root injury.
STUDY DESIGN Behavioral and immunohistochemical analysis in rat models of persistent and transient allodynia. OBJECTIVES To examine separate cervical nerve root injuries (compression, transection) for producing behavioral hypersensitivity and investigate spinal neuropeptides to understand relationships to pain symptoms. SUMMARY OF BACKGROUND DATA Mechanical cervical nerve root injury can be...
متن کاملThe role of graded nerve root compression on axonal damage, neuropeptide changes, and pain-related behaviors.
Rapid neck motions can load cervical nerve roots and produce persistent pain. This study investigated the cellular basis of radicular pain and mechanical implications of tissue loading rate. A range of peak loads was applied in an in vivo rat model of dorsal root compression, and mechanical allodynia (i.e. pain) was measured. Axonal damage and nociceptive mediators were assessed in the axons an...
متن کاملTransient nerve root compression load and duration differentially mediate behavioral sensitivity and associated spinal astrocyte activation and mGLuR5 expression.
Injury to the cervical nerve roots is a common source of neck pain. Animal models of nerve root compression have previously established the role of compression magnitude and duration in nerve root-mediated pain and spinal inflammation; yet, the response of the spinal glutamatergic system to transient nerve root compression and its relationship to compression mechanics have not been studied. The...
متن کاملTransient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries.
STUDY DESIGN An in vivo rat model of transient cervical nerve root compression. OBJECTIVES To investigate the potential for cervical nerve root compression to produce behavioral hypersensitivity and examine its dependence on compression. SUMMARY OF BACKGROUND DATA Clinically, nerve root injury has been hypothesized as a potential source of neck pain, particularly because cervical nerve root...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2008
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2007.09.026